If I may verify the processing times involved in NIW. Since it falls under EB2 category, I am assuming it may be a long time before I can get my EAD card and be able to change employers. Also, I want to confirm if there could be issues if I change employers during the process - If so, I'd prefer to change my current employer before starting with it.
You can change employers any time if you are a self-applicant and will continue to work in your stated area of national interest. But NIW priority date will take the same time as a normal EB-2 application does. See:
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Can I qualify for RN based H-1 if I have only an Associate degree in nursing?
The simple answer is, no, unless you also have 6 years of professional experience. Also note, not all RN's can qualify for an H-1.